introductory literature

"Initiative Phytopharmaka", DGPharMed-Department for Clinical Trials:

Dörr, B., Hellhammer, J., Klüting, A., Strehl, C., Surjo, D., Wonnemann, M. (2022).
Pflanzen und deren Zubereitungen in Arzneimitteln und Lebensmitteln – Teil 4: Entscheidend ist die Zweckbestimmung.
Pflanzliche Zubereitungen als Arzneimittel oder Lebensmittel – Beispiel einer Abgrenzung.
PM QM Fachzeitschrift für pharmazeutische Medizin und Qualitätsmanagement, 2-2022: 38-48.
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Dörr, B., Hellhammer, J., Klüting, A., Strehl, C., Surjo, D., Wonnemann, M. (2022).
Pflanzen und deren Zubereitungen in Arzneimitteln und Lebensmitteln – Teil 3: Besondere Herausforderungen bei nicht-klinischen und klinischen Untersuchungen.
Spezielle Aspekte und Hürden in der Entwicklung von Phytopharmaka.
PM QM Fachzeitschrift für pharmazeutische Medizin und Qualitätsmanagement, 1-2022: 28-38.
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Dörr, B., Hellhammer, J., Klüting, A., Strehl, C., Wonnemann, M. (2021).
Pflanzen und deren Zubereitungen in Arzneimitteln und Lebensmitteln – Teil 2: Entscheidend für die Marktzulassung ist die Zweckbestimmung.
Pflanzliche Zubereitungen in Nahrungsergänzungsmitteln und bilanzierten Diäten.
PM QM Fachzeitschrift für pharmazeutische Medizin und Qualitätsmanagement, 3-2021: 172-178.
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Dörr, B., Hellhammer, J., Klüting, A., Strehl, C., Wonnemann, M. (2021).
Pflanzen und deren Zubereitungen in Arzneimitteln und Lebensmitteln – Teil 1: Entscheidend für die Marktzulassung ist die Zweckbestimmung.
Pflanzliche Arzneimittel: Zulassungsarten und spezielle Herausforderungen im Überblick.
PM QM Fachzeitschrift für pharmazeutische Medizin und Qualitätsmanagement, 2-2021: 102-109.
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Bamberger, M., Leverkus, F., Hellhammer, J., Esser, M., Breitkopf, S. (2020).
Klinische Prüfungen mit Psychopharmaka aus Sicht der frühen Nutzenbewertung.
PM QM Fachzeitschrift für pharmazeutische Medizin und Qualitätsmanagement, 2-2020: 86-91.
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Hellhammer, D.H.,  Stone, A.A., Hellhammer, J.,  Broderick, J. (2010).
Measuring Stress. In: Koob, G.F., Le Moal, M. & Thompson, R.F. (Ed.) Encyclopedia of Behavioral Neuroscience, Vol. 2: S. 186-191. Oxford: Academic Press.

Introductory Literature - please contact us if you are interested in receiving further literature.


Patterson, E., Griffin, S. M., Ibarra, A., Ellsiepen, E., Hellhammer, J. (2020).
Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study).
Neurobiology of Stress, 13, 100277, ISSN 2352-2895,

de Jong, T. R., Menon, R., Bludau, A., Grund, T., Biermeier, V., Klampfl, S. M., Jurek, B., Bosch, O. J., Hellhammer, J. & Neumann, I. D. (2015).
Salivary oxytocin concentrations in response to running, sexualself-stimulation, breastfeeding and TSST: The RegensburgOxytocin Challenge (ROC) study.
Psychoneuroendocrinology 62: 381-388

Hellhammer, J., Vogt, D., Franz, N., Freitas, U. & Rutenberg, D. (2014).
The soy-based phosphatidylserine/phosphatidic acid complex MemreePlus normalizes the stress reactivity of hypothalamus-pituitary-adrenal-axis in chronically stressed male subjects: A randomized, placebo-controlled study. Lipids in Health and Disease, 13:121 -131

Biehle-Hulette, S. J., Krailler, J. M.,  Elstun, L. T., Bentz, S., Benzing, K. W., Spruell, R. D., Hellhammer, J. & Swaile, D.F. (2014).
Thermoregulatory vs. event sweating – comparison of clinical methodologies, physiology and results.
International Journal of Cosmetic Science, 36: 102-108.

Schmidt-Rose, T., Lehmbeck, F., Bürger, A., Windisch, B., Keyhani, R. & Max, H. (2013).
Efficient sweat reduction of three different antiperspirant application forms during stress-induced sweating.
International Journal of Cosmetic Science, 35(6): 622-31.

Hellhammer, J. & Schubert, M. (2013).  
Effects of a homeopathic combination remedy on the acute stress response, wellbeing and sleep: A double blind, randomized clinical trial. Journal of Alternative and Complementary Medicine, 19(2): 161-196.

Hellhammer, J., Hero, T., Franz, F., Contreras, C., Schubert, M. (2012).
Stress dampening effects of omega-3 phosphatidylserine on acute and chronic stress.
Nutrition Research, 32: 241-250.

Hellhammer, J. & Schubert, M. (2012).  
The physiological response to Trier Social Stress Test relates to subjective measures of stress during but not before or after the test.
Psychoneuroendocrinology, 37: 119-124.

Schubert, M., Contreras, C., Franz, N., Hellhammer, J. (2011).  
Milk-based phospholipids increase morning cortisol availability and improve memory in chronically stressed males.
Nutrition Research, 31: 413-420.

Martin, A., Hellhammer, J., Hero, T., Schult, J., Terstegen, L. (2010).
Effective prevention of stress-induced sweating and axillary malodor formation in teenagers.
International Journal of Cosmetic Science, 33: 90-97.

Hellhammer, J., Waladkhani, A.-R., Hero, T., Buss, C. (2010).  
Effects of milk phospholipid on memory and psychological stress response.
British Food Journal, 112: 1124-1137.

Schult, J., Hero, T. & Hellhammer, J. (2010).
Effects of powdered fertilized eggs on stress response.
Clinical Nutrition, 29, 255-260.

Vinkers, C.H., Penning, R., Ebbens, M.M., Hellhammer, J.,Verster, J.C., Kalkman, C.J., Olivier, B. (2010).
Stress-Induced Hyperthermia in Translational Stress Research.
The Open Pharmacology Journal, 4: 30-35.

Hellhammer, D.H.,  Stone, A.A., Hellhammer, J., Broderick, J. (2010).
Measuring Stress (S. 186-191). In: Koob, G.F., Le Moal, M. & Thompson, R.F. (Hrsg.) Encyclopedia of Behavioral Neuroscience, Bd. 2: S. 186-191. Oxford: Academic Press. 

Hellhammer, J., et al. (2009).
Percieved Stress and Diabetes Management in Patients with Type 1 and Type 2 Diabetes - Results for a Pilot Study.
Diabetes, 58.

Hellhammer, J., Hero, T., Hellhammer, K. (2008).
The TSSTplus: A new modulary laboratory protocol for the assessment of stress and social anxiety.
The International Journal of Neuropsychopharmacolgy, 11, Supplement 1: 286.

Hellhammer, J., Fries, E., Schweisthal, O.W., Schlotz, W., Stone, A.A. Hagemann, D. (2007).
Several daily measurements are necessary to reliably assess the cortisol rise after awakening: State and trait components.
Psychoneuroendocrinology, 32: 80-86.

Fries, E., Hellhammer, D.H. & Hellhammer, J. (2006).
Attenuation of the hypothalamic-pituitary-adrenal axis responsivity to the Trier Social Stress Test by the benzodiazepine alprazolam.
Psychoneuroendocrinology, 31: 1278-1288.

Hellhammer, J., Fries, E., & Hero, T. (2006).
Psychological stress and body temperature: Effects of Alprazolam and Flupentixol.
Biological Psychiatry and Psychopharmacology, 8: 25.

Hellhammer, J., Fries, E. & Hellhammer, D.H. (2005).
The Trier Social Stress Test (TSST): A sensitive tool for the discrimination of anxiolytic drug effects.
Presented at the 44th Annual Meeting of the American College of Neuropsychopharmacology.

Hellhammer, J., Fries, E., Buss, C., Engert, V., Rutenberg, D., Hellhammer, D.H. (2004).
Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine response to mental stress.
Stress, 7(2): 119-126.

Kirschbaum, C., Pirke, K.-M. & Hellhammer, D. H. (1993).
The Trier Social Stress Test- A tool for investigating psychobiological stress responses in a laboratory setting.
Neuropsychobiology, 28: 76-81. 


Contreras, C., Gerhards, F., Hellhammer, J. (2020).
neuropattern - ein translationales Verfahren zur Stressreduktion am Arbeitsplatz.
ASU Arbeitsmedizin Sozialmedizin Umweltmedizin 2020; 55: 317-322
Link (Open Access, abstract in English)

Bergemann, N., Bruhn, K., Loscheider, K., Vogt, D., Böhnke, J.R., Gerhards, F. (2019).
How to dertermine whether conceptual endophenotypes can improve clinical outcomes in patients suffering from major depression: An exploratory approach.
Psychoneuroendocrinology; 105: 195-204.

Contreras, C., Hellhammer, J., Gerhards, F., Hellhammer, D. H. (2018).
Neuropattern, a Translational Tool to Reduce Stress at Work - a Pilot Study.
Occupational Health Science; 2: 385-407.

Hellhammer, D., Meinlschmidt, G., Pruessner, J. C. (2018).
Conceptual endophenotypes: A strategy to advance the impact of psychoneuroendocrinology in precision medicine.
Psychoneuroendocrinology; 89: 147-160.

Waeldin, S., Vogt, D., Linden, M. & Hellhammer, D. (2016).
Frequency of Perceived Poststress Symptoms in Inpatients, Outpatients and Healthy Controls: The Roles of Perceived Exhaustion and Stress.
psychother Psychosom; 85: 36-44.

Waeldin, S., Vogt, D. & Hellhammer, D. (2015).
Subjektive Erschöpfung bei stressbezogenen Gesundheitsstörungen: Auswirkungen auf die Inanspruchnahme von Gesundheitsleistungen, die Arbeitsfähigkeit und das Wohlbefinden. (Subjective Exhaustion in Stress-Related Disorders: Effects on the Utilization of Health Care, on Work Ability, and on Well-Being.) Zeitschrift für Gesundheitspsychologie; 2:89-99.

Boyle, K. S. & Hellhammer, D. H. (2013).
Neuropattern: Sieben Schritte zu einer translationalen Stressmedizin.
Verhaltenstherapie & Verhaltensmedizin; 34 (3): 237-250

Hellhammer, D.H., Hero, T., Gerhards, F., Hellhammer, J. (2012).
Neuropattern: A new translational tool to detect and treat stress pathology. I. Strategical consideration.
Stress; 15 (5): 479-487.

Hero, T., Gerhards, F., Thiart, H., Hellhammer, D.H.,  Linden, M. (2012).
Neuropattern: A new translational tool to detect and treat stress pathology. II. The Teltow Study.
Stress; 15 (5): 488-494.



Hellhammer, D.H. & Hellhammer, J. (2011).
Neurobehavioral Medicine: From Bench to Bedside.
In: New Directions in Organisational Psychology and Behavioural Medicine. Antoniou, A.-S. & Cooper, C.L., Pages 63-76, Ashgate: London.

Hellhammer, D.H. & Hellhammer, J. (2010).
Neuropattern: Psychobiologische Diagnostik für die Praxis.
In: Bergemann, N. (Hrsg) Aktuelle Behandlungskonzepte psychischer Erkrankungen.
Wolfsbrunnen-Verlag: Heidelberg: 1-20.

Hero, T., Krisch, A., Puetz, P., Hellhammer, J., Hellhammer, D.H. (2008).
Novem-Analyses - I: A simple method for the analysis of the cortisol awakening response.
Poster presenation at the XXXIX. Annual ISPNE Conference.

Waladkhani, A.R. & Hellhammer, J. (2008).
Dietary modification of brain function: effects on neuroendocrine and psychological determinants of mental health and stress related disorders.
Advances in Clinical Chemistry, 45: 99-138.

Hellhammer, D.H. & Hellhammer, J. (Hrsg.) (2008).
Stress: The Brain-Body Connection.
Karger: Basel

Hellhammer, D.H. (2005).
Neuropattern - ein innovatives psychobiologisches Verfahren zur Prävention, Diagnostik und Behandlung von stressbezogenen Gesundheitsstörungen.
Report Psychologie, 7/8: 312-316.

Fries E., Hesse J., Hellhammer J., Hellhammer D.H. (2005). A new view on hypocortisolism. Psychoneuroendocrinology, 30(10):1010-6.

Hellhammer, J. & Hellhammer, D.H. (2004).
Ein neuer Weg in der Stressdiagnostik: Neuropattern.
In: Stubbe, H. & Follmann, W. (Hrsg.). Interventionen in der angewandten Psychologie.
Shaker Verlag: Aachen: 19-26.

Hellhammer, J., Schlotz, W., Stone, A.A., Pirke, K.M., Hellhammer, D.H. (2004).
Allostatic Load, Perceived Stress, and Health: A Prospective Study in Two Age Groups. In: Yehuda R. and B. McEwen (Hrsg.). Biobehavioral Stress Response: Protective and Damaging Effects.
Annals of the New York Academy of Sciences, 1032: 8-13.

Further literature

Eckert, F., Meyer, N., Monzel, E., Bouvret, E., Chataigner, M., Hellhammer, J. (2024).
Efficacy of a Fish Hydrolysate Supplement on Sleep Quality: A Randomized, Double-Blind, Placebo-controlled , Crossover Clinical Trial.
Clinical Nutrition ESPEN,

Hellhammer, J., Spitznagel-Schminke, L., Hufnagel, R. (2023).
Kalium phosphoricum comp. in patients with neurasthenia: a randomized, double-blind, placebo-controlled clinical trial.
Current Medical Research and Opinion,

Hellhammer, J., Schmidt, K., Semaca, C., Hufnagel, R. (2022). Neurodoron® for Stress Impairments: A Prospective, Multicenter Non-Interventional Trial.
Evidence-Based Complementary and Alternative Medicine, vol. 2022, Article ID 2626645,

Edwards, K. D., Dubberke, A., Meyer, N., Kugel, S., Hellhammer, J. (2021).
Assessment of the Effects of a Sage (Salvia officinalis) Extract on Cognitive Performance in Adolescents and Young Adults.
medRxiv 2021.05.28.21257776;

Dubberke, A., Ellsiepen, E., Nisius, F., Hellhammer, J. (2019).
Impact of morning cortisol and evening melatonin secretion on sleep quality.
Journal of Neural Transmission (2019) 126:1519;

Dubberke, A., Ellsiepen, E., Nisius, F., Hellhammer, J. (2019).
Sleep quality and salivary melatonin and cortisol secretion: A pilot study testing the feasibility of a user-friendly ambulant design.
Psychoneuroendocrinology 107(S): 32.

Pouteau, E., Kabir-Ahmadi, M., Noah, L., Mazur, A., Dye, L., Hellhammer, J., et al. (2018).
Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial.
PLoS ONE, 13(12): e0208454;

Schmidt, K., Weber, N., Steiner, M., Meyer, N., Dubberke, A., Rutenberg, D., Hellhammer, J. (2018).
A lecithin phosphatidylserine and phosphatidic acid complex (PAS) reduces symptoms of the premenstrual syndrome (PMS): Results of a randomized, placebo-controlled, double-blind clinical trial.
Clinical Nutrition ESPEN;

Olbrich, D., Näher, K. (2017).
Veränderungen der Cortisol-Aufwachreaktion (CAR) nach Stimulation mit frequenzmodulierter Musik (AVWF®) – Ergebnisse aus der psychosomatischen Rehabilitation.
Ärztliche Psychotherapie und Psychosomatische Medizin, 12(1): 43-9.

Pfützner, J., Hellhammer, J., Musholt, P., Pfützner, A.H., Böhnke, J., Hero, T., Amann-Zalan, I., Ganz, M., Forst, T., Pfützner, A. (2011).
Evaluation of dexterity in insulin-treated patients with type 1 and type 2 diabetes mellitus.
Journal of Diabetes Science and Technology, 5, 158-165.