TSST - Trier Social Stress Test

The growing influence of stress on health increasingly called for a test method that reliably induces stress in humans.

The search was for a stress test, which provoked psychological and biological stress reactions in the laboratory. To this purpose, Dirk
Hellhammer and his research team at the University of Trier developed the Trier Social Stress Test (short TSST; 1993).

Today, the method is internationally recognized as the
most reliable, most valid and best standardized method to assess anxiety and acute stress in humans under laboratory conditions (see also a metaanalysis of stress tests from Dickerson & Kemeny, 2004). Variations of the classic TSST and other provocation tests exist and can be applied depending on the research question.

daacro has many years of experience and a high level of expertise in the application of this method according to ICH-GCP Guidelines.
We have been able to show that the TSST is not only a sensitive test for the development of anxiolytics, but can also be used to achieve resilient study results for herbals, botanicals and nutritional supplements in many other applications.

The large number of TSSTs that daacro has performed over the past years has lead to a continuous and profound growth of knowledge about the stress reaction. Every year, our work produces further knowledge and further biomarkers are established. The comparability of the data is unsurpassed.

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[Translate to English:] Hellhammer, J. & Schubert, M. (2012). The physiological response to Trier Social Stress Test relates to subjective measures of stress during but not before or after the test. Psychoneuroendocrinology, 37: 119-124.